Improved oxygenation by nitric oxide is enhanced by prior lung reaeration with surfactant, rather than positive end-expiratory pressure, in lung-lavaged rabbits
نویسندگان
چکیده
منابع مشابه
Feasibility of neurally adjusted positive end-expiratory pressure in rabbits with early experimental lung injury
BACKGROUND During conventional Neurally Adjusted Ventilatory Assist (NAVA), the electrical activity of the diaphragm (EAdi) is used for triggering and cycling-off inspiratory assist, with a fixed PEEP (so called "Triggered Neurally Adjusted Ventilatory Assist" or "tNAVA"). However, significant post-inspiratory activity of the diaphragm can occur, believed to play a role in maintaining end-expir...
متن کاملPositive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep.
The initiation of ventilation in preterm, surfactant-deficient sheep without positive end-expiratory pressure (PEEP) causes airway injury and lung inflammation. We hypothesized that PEEP and surfactant treatment would decrease the lung injury from initiation of ventilation with high tidal volumes. Fetal sheep at 128-day gestational age were randomized to ventilation with: 1) no PEEP, no surfact...
متن کاملReducing tidal volume and increasing positive end-expiratory pressure with constant plateau pressure during one-lung ventilation: effect on oxygenation.
BACKGROUND It is no longer safe to use large tidal volumes (V(T)) (>8 ml kg(-1)) for one-lung ventilation (OLV), and limiting plateau pressure should be a major objective. Due to the specificity of OLV, the use of positive end-expiratory pressure (PEEP) remains controversial. This study determined whether at the same low plateau pressure, reducing V(T) and increasing PEEP were not inferior to l...
متن کاملOptimization of positive end-expiratory pressure by volumetric capnography variables in lavage-induced acute lung injury.
BACKGROUND In the acute respiratory distress syndrome (ARDS), lung-protective ventilation strategies combine the delivery of small tidal volumes (VT) with sufficient positive end-expiratory pressure (PEEP). However, an optimal approach guiding the setting of PEEP has not been defined. Monitoring volumetric capnography is useful to detect changes in lung aeration. OBJECTIVES The aim of this st...
متن کاملLung reaeration after surfactant instillation - caused by surfactant or caused by instillation?
signifi cant and prolonged lung reaeration after intratracheal bolus instillation of porcine-derived surfactant. In this substudy of a larger randomized controlled trial of patients with acute lung injury [2], the investigators elegantly demonstrate increased volumes of gas in poorly and non-aerated lung of patients who were treated with surfactant as compared with patients who received routine...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 1997
ISSN: 0090-3493
DOI: 10.1097/00003246-199711000-00027